34 Results for "

Caesalpinia sappan L.

" in MedChemExpress (MCE) Product Catalog:
Products (34)

34 Results for "Caesalpinia sappan L." in MCE Product Catalog:

11
Hematoxylin
Hematoxylin
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11 Publications Verification
Art. -Nr.: HY-N0116
CAS. Nr.: 517-28-2
Synonyms: Natural Black 1; Haematoxylin
Category:  

Leguminosae Caesalpinia sappan L. Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

Amyloid-β

Hematoxylin (Natural Black 1), a naturally occurring flavonoid compound derived from Caesalpinia sappan Linn.. Hematoxylin is a nuclear stain in histology and is also a potent Aβ42 fibrillogenesis inhibitor with an IC50 of 1.6 μM.
8
Sappanone A
Sappanone A
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8 Cited Publications
Art. -Nr.: HY-113556
CAS. Nr.: 102067-84-5
Reinheit:  99.87%
Category:  

Flavonoids Leguminosae Caesalpinia sappan L. Plants Disease Research Fields Inflammation/Immunology Isoflavones

Target:  

Phosphodiesterase (PDE) NF-κB Keap1-Nrf2 Reactive Oxygen Species (ROS) TNF Receptor Nuclear Factor of activated T Cells (NFAT) Akt ERK p38 MAPK NO Synthase Interleukin Related COX JNK

Sappanone A is an orally active homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-κB inhibitor with anti-inflammatory and antioxidant effect. Sappanone A induces HO-1 expression through activation of Nrf2 pathway. Sappanone A also inhibits RANKL-induced osteoclastogenesis. Sappanone A has great potential in the research of inflammation-related and cardiovascular .
2
Protosappanin B
Protosappanin B
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2 Cited Publications
Art. -Nr.: HY-N0800
CAS. Nr.: 102036-29-3
Synonyms: (-)-Protosappanin B
Category:  

Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Disease Research Fields Cancer

Target:  

Apoptosis

Protosappanin B is a phenolic compound extracted from Caesalpinia sappan. Anti-cancer activity . Protosappanin B induces apoptosis and causes G1 cell cycle arrest in human bladder cancer cells .
2
3-Deoxysappanchalcone
3-Deoxysappanchalcone
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2 Cited Publications
Art. -Nr.: HY-N1745A
CAS. Nr.: 112408-67-0
Category:  

Flavonoids Chalcones Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Reactive Oxygen Species (ROS) Apoptosis

3-Deoxysappanchalcone is a natural chalcone compound isolated from the heartwood of Caesalpinia sappan L. 3-Deoxysappanchalcone induces cell cycle arrest, ROS production, and apoptosis. 3-Deoxysappanchalcone exhibits anti-inflammatory, anti-allergic, anticoagulant, and antithrombotic activities. 3-Deoxysappanchalcone is applicable to research related to lung cancer, esophageal squamous cell carcinoma, thrombosis, and influenza virus infection .
Protosappanin A
Protosappanin A
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Art. -Nr.: HY-113573
CAS. Nr.: 102036-28-2
Reinheit:  99.98%
Synonyms: PTA
Category:  

Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Interleukin Related JAK STAT

Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3 .
7,3',4'-Trihydroxy-3-benzyl-2H-chromene
7,3',4'-Trihydroxy-3-benzyl-2H-chromene
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Art. -Nr.: HY-N2735
CAS. Nr.: 1111897-60-9
Category:  

Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants

Target:  

Influenza Virus

7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC50 values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus .
Norcaesalpinin E
Norcaesalpinin E
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Art. -Nr.: HY-N7583
CAS. Nr.: 854038-96-3
Category:  

Leguminosae Caesalpinia crista L. Terpenoids Diterpenoids Plants

Target:  

Parasite

Norcaesalpinin E, a C-17-norcassane-type diterpene found in Caesalpinia crista, is a Plasmodium falciparum growth inhibitor with an IC50 of 90 nM. Norcaesalpinin E induces dose-dependent growth inhibition of Plasmodium falciparum. Norcaesalpinin E can be used for the research of malaria .
Sappanchalcone
Sappanchalcone
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Art. -Nr.: HY-59001
CAS. Nr.: 94344-54-4
Category:  

Flavonoids Chalcones Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Disease Research Fields Cancer

Target:  

Apoptosis

Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells .
Caesalpine A
Caesalpine A
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Art. -Nr.: HY-133225
CAS. Nr.: 1616757-59-5
Category:  

Leguminosae Terpenoids Diterpenoids Plants Guilandina minax (Hance) G. P. Lewis

Target:  

Others

Caesalpine A, a cassane-type diterpene, is a natural product that could be isolated from the seeds of Caesalpinia minax .
4-O-Methylepisappanol
4-O-Methylepisappanol
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Art. -Nr.: HY-N10843
CAS. Nr.: 112529-37-0
Category:  

Flavanonols Flavonoids Caesalpiniaceae Plants

Target:  

Influenza Virus

4-O-Methylepisappanol (compound 9) is nature product that could be isolated from heartwood of Caesalpinia sappan. 4-O-Methylepisappanol is a potent neuraminidase inhibitor on the surface of influenza viruses with IC50 values of 42.8, 63.2, and 63.2 µM for A/Chicken/Korea/MS96/96 [H9N2], A/PR/8/34 [H1N1], and A/Hong Kong/8/68 [H3N2], respectively .
3-(4-Nitrophenyl)-1H-pyrazol-5(4H)-one
3-(4-Nitrophenyl)-1H-pyrazol-5(4H)-one
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Art. -Nr.: HY-403587
CAS. Nr.: 54945-13-0
Category:  

Natural Products Caesalpiniaceae Plants

Target:  

Others

3-(4-Nitrophenyl)-1H-pyrazol-5(4H)-one is a natural product found in Caesalpinia sappan. Caesalpinia sappan contains various phytochemicals and is considered a plant with significant medicinal value .
Episappanol
Episappanol
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Art. -Nr.: HY-N9315
CAS. Nr.: 111254-18-3
Category:  

Other Terpenoids Leguminosae Caesalpinia sappan L. Terpenoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

TNF Receptor Interleukin Related

Episappanol is a natural compound isolated from Caesalpinia sappan heartwood with anti-inflammatory activity. Episappanol significantly inhibits the IL-6 and TNF-α secretion .
Deoxysappanone B
Deoxysappanone B
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Art. -Nr.: HY-N1818
CAS. Nr.: 113122-54-6
Synonyms: 3-Deoxysappanone B
Category:  

Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants

Target:  

p38 MAPK

Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage .
Caesappanin C
Caesappanin C
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Art. -Nr.: HY-N4299
CAS. Nr.: 1913319-59-1
Category:  

Leguminosae Caesalpinia sappan L. Metabolic Disease Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields

Target:  

HSV HSP

Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration . Caesappanin C can effectively deactivate HSV particles and bind HSV surface glycoprotein B (gB) to inhibit membrane fusion .
Bonducellin
Bonducellin
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Art. -Nr.: HY-N10069
CAS. Nr.: 83162-84-9
Category:  

Flavonoids Leguminosae Caesalpinia sappan L. Plants Other Flavonoids

Target:  

Bacterial

Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L) .
Caesalmin B
Caesalmin B
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Art. -Nr.: HY-N2981
CAS. Nr.: 352658-23-2
Category:  

Infection Other Terpenoids Leguminosae Terpenoids Plants Disease Research Fields Caesalpinia crista L.

Target:  

Antibiotic

Caesalmin B is a furanoditerpenoid lactone isolated from Caesalpinia minax. Caesalmin B exhibits antiviral activity .
7-Hydroxy-3-(4-hydroxybenzylidene)chroman-4-one
7-Hydroxy-3-(4-hydroxybenzylidene)chroman-4-one
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Art. -Nr.: HY-44135
CAS. Nr.: 110064-50-1
Category:  

Flavonoids Leguminosae Caesalpinia sappan L. Plants Other Flavonoids

Target:  

Others

7-Hydroxy-3-(4-hydroxybenzylidene)chroman-4-one, a homoisoflavonoid, can be isolated from the dried heartwood of Caesalpinia sappan .
7-Acetoxybonducellpin C
7-Acetoxybonducellpin C
0 Images
Art. -Nr.: HY-N2753
CAS. Nr.: 197781-86-5
Category:  

Leguminosae Caesalpinia crista L. Terpenoids Diterpenoids Plants

Target:  

Parasite

7-Acetoxybonducellpin C, a diterpenoid, is a nature product that could be isolated from the seed kernels of Caesalpinia crista. 7-Acetoxybonducellpin C has antimalarial activity .
Protosappanin A dimethyl acetal
Protosappanin A dimethyl acetal
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Art. -Nr.: HY-N10108
CAS. Nr.: 868405-37-2
Category:  

Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants

Target:  

Xanthine Oxidase

Protosappanin A dimethyl acetal is a homoisoflavonoid. Protosappanin A dimethyl acetal can be isolated from Caesalpinia sappan. Protosappanin A dimethyl acetal is also a competive inhibitor with significant xanthine oxidase inhibitory activity (IC50=50.7 μM) .
Protosappanin B (Standard)
Protosappanin B (Standard)
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Art. -Nr.: HY-N0800R
CAS. Nr.: 102036-29-3
Synonyms: (-)-Protosappanin B (Standard)
Category:  

Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants

Target:  

Reference Standards Apoptosis

Protosappanin B (Standard) is the analytical standard of Protosappanin B. This product is intended for research and analytical applications. Protosappanin B is a phenolic compound extracted from Caesalpinia sappan. Anti-cancer activity . Protosappanin B induces apoptosis and causes G1 cell cycle arrest in human bladder cancer cells .
Assay Types